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While TGF-β1 decreases basal OCR in mink lung epithelial cells (Yoon et al., 2005), breast cancer cells (Lee et al., 2016), and activated human effector memory CD4 + T cells (Dimeloe et al., 2019), it increases basal and maximal OCR in mouse podocytes (Abe et al., 2013) and human fibroblasts (Selvarajah et al., 2019)

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Open questions Considering the characteristics of the heart as a blood-pumping organ, do more intracellular factors need to be considered when targeting NAD+ signals