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Thus, the type I cells of all three species respond to hypoxia and hypoglycemia by increasing the cytosolic Ca 2+ and releasing catecholamines

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3.2.5 Elucidation of mechanism of action using transcriptomics Here, we explored the potential utility of transcriptomics as a technology, not only for establishing a PoD but also for gaining mechanistic insights to generate hypotheses within the context of a risk assessment framework