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They conducted a literature search and found that the most common symptoms were gastrointestinal, followed by neurological adverse events, while psychiatric adverse events were less common ( Abusafiyah and Soulen searched the FDA Adverse Event Reporting System (FAERS) database for a timeframe of 10 years and found the following numbers of psychiatric side effects: for Beta-Lactam antibiotics, 2,217 severe psychiatric side effects were reported

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Animal Model Evidence The systemic evidence base is entirely preclinical: Pulmonary fibrosis (mouse model): Intraperitoneal GHK-Cu at 0.2-20 micrograms/g/day protected against bleomycin-induced lung fibrosis by inhibiting TGF-beta1/Smad signaling and reducing oxidative stress (PMID 31809714)