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295 In all inhibitors of WNT signalling, niclosamide is FDA-approved drug and was used to treat taeniasis, showing inhibiting effect on tumours proliferation, stemness and metastasis by causing FZD1 receptor internalization and decreasing the protein level of DVL2, as well as targeting LRP6

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On the other hand, if the protein contains no recognizable motifs and has no similarity to other proteins, yet contains many cysteine residues, other strategies and precautions would be warranted as described in UNITS 6.3–6.5