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FIGURE 2 N-terminal ubiquitylation Met1-linked polyubiquitin The best characterized example of non-lysine ubiquitylation involves the formation of a peptide bond between the carboxy-terminus of an incoming ‘donor’ ubiquitin and the amino-terminus of the preceding ‘acceptor’ ubiquitin to generate so-called ‘linear’ or Met1-linked polyubiquitin chains, key players in immune signaling and cell death regulation (linear ubiquitylation has been extensively reviewed elsewhere and the reader is directed towards one of the many excellent reviews on the subject, such as Elliott 2016, Hrdinka and Gyrd-Hansen 2017, Rittinger and Ikeda 2017, Dittmar and Winklhofer 2019, Oikawa et al., 2020, Fuseya and Iwai 2021, or Jahan et al., 2021)
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