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At this stage, the hemato­logical defects are indistinguishable from those of folate deficiency and include megalo­blastic anemia, characterized by macro-ovalocytic erythrocytes, abnormal red cell indices, and a low hemoglobin concen­tration (see Chapter 17, Sections 17.2.7 and 17.4)

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In osteoporosis, both miR-29b-3p and miR-378g regulate osteogenic differentiation of BMSCs by targeting NNMT