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Though the level of statistical significance was not reached, patients with Hashimoto hypothyroidism preferred DTE or combination levothyroxine sodium and liothyronine sodium over levothyroxine sodium treatment alone.3 One review of 125 patients who switched from levothyroxine sodium treatment alone to DTE (specifically, Armour Thyroid in the case of this study) found patients complained less of weight gain and fatigue when in a euthyroid state on DTE as compared to levothyroxine sodium

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