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Modern research validates this traditional wisdom: berberine demonstrates broad-spectrum antimicrobial activity against bacteria, fungi, parasites, and protozoa, with minimum inhibitory concentrations of 4–64 µg/mL against pathogens including C

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In the HK-2 model induced by HG, hypoxia-inducible factor-1α (HIF-1α) promotes PINK1/Parkin-mediated mitophagy to alleviate high glucose-induced cell damage [119]