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Recent findings highlight oxidative stress and inflammation as pivotal factors in drug-induced disruption of brain homeostasis (Berrios-Carcamo et al., 2015), cocaine (Periyasamy et al., 2018), ethanol, nicotine (Alfonso-Loeches et al., 2018, 2019), opioids (Wang et al., 2012), and cannabinoids (Cutando et al., 2015)