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S100β S100β is a low-molecular-weight glial protein (45) that does not circulate in the blood of healthy individuals, but it can be released and detected in the peripheral blood after BBB injury

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they believe their finding could have “therapeutic implications for relieving fatigue symptoms in ME/CFS.” They suggested that a similar scenario may be playing out in long COVID and other fatiguing rheumatic diseases such as fibromyalgia and rheumatoid arthritis