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2.1 Glucose metabolism The normal cellular energy metabolism process begins with the acquisition of energy and pyruvic acid through glycolysis in the cytoplasm under aerobic conditions, followed by oxidative phosphorylation of pyruvic acid to acetyl-CoA in the mitochondria, entering the tricarboxylic acid cycle (TCA cycle), or conversion of pyruvic acid to lactic acid in the cytoplasm under anaerobic conditions ( Figure 1 )