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Recent research findings have identified multiple immune mechanisms and signaling pathways in the pathogenesis of vitiligo, including the JAK/STAT signaling pathway, the IFN-γ-CXCL9/10-CXCR3 pathway, Tregs, and tissue-resident memory T cells

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SIRT1 is a Mediator of Caloric Restriction Several studies have clearly demonstrated that moderate caloric restriction (CR) slows aging, extending life span up to 30–50% [61], furthermore CR can protect animals from the development of metabolic syndrome [61]