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Alternatively, or in addition, it is also possible that: 1) lysate-based approaches employed in the S -thiolation proteomic studies resulted in fewer identifications and, therefore, lower overlap with the “sulfenome”, and/or 2) the modest rate constant for the reaction of many dimedone analogs with sulfenic acid (~10 3 M −1 min −1 ) may not be sufficient to trap especially transient modifications