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These agents limit estrogen production, cause decidualization of ectopic endometrial tissue, and subsequently result in atrophy of endometrial cells

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For example, compared to CRPC_AR subtype, the AR -/lo subtypes of CRPC, i.e., CRPC_Wnt and CRPC_NE, manifest notably more open chromatin regions (i.e., ATAC peaks) across the BCL-2 genomic region in association with higher BCL-2 transcription (supplementary Fig