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Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks - PMC

Specifically, in a ModA16 ON state, NTHi upregulates multiple iron-acquisition factors including an iron ABC transporter substrate-binding protein, and haem/haemopexin-binding proteins HxuC and HxuB (Tram et al., 2024)

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Pathological staging also significantly impacts the selection of protective strategies—melatonin levels are significantly reduced in tumor patients, with advanced cervical cancer patients showing notably lower melatonin levels than early-stage patients, which suppresses melatonin’s protective effects in vivo (194)