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This deactivation of MKPs allows for the unimpeded progression and sustained activation of the pro-inflammatory ERK1/2, JNK, and p38 signaling cascade within the MAPK pathway ( Astrocytes, the major glial support cells in the CNS, are indispensable in the regulation of GSH homeostasis

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However, results vary depending on the cause of the condition, the type of injection used, and individual patient factors