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Therapeutically, node-specific, compartment-aware interventions—tuning NOX/NOS activity, reinforcing mitochondrial quality control, alleviating ER stress, managing iron and suppressing ferroptosis when indicated and providing calibrated RSS support—consistently outperform blanket antioxidant scavenging by preserving beneficial H 2 O 2 -based signalling while preventing convergence onto damaging chemistries such as peroxynitrite formation, Fenton-driven hydroxyl radicals and runaway lipid peroxidation (Li et al
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