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In the situation of I/R injury, NSAIDs have been shown to attenuate the production of pro-inflammatory cytokines (e.g., TNF- α , IL-6) and reduce microglial activation, which are key drivers of neuroinflammation (Ajmone-Cat et al., 2010)

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Cos7, MCF7 and HEK293 cells were grown in Dulbecco’s modified Eagle’s medium (DMEM) containing 10% foetal calf serum (FCS) and penicillin-streptomycin (Invitrogen)