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Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes: Neuron

doi: 10.3389/fimmu.2024.1462805 Received 10 July 2024 Accepted 23 September 2024 Published 11 October 2024 Volume 15 - 2024 Edited by Isabelle Bekeredjian-Ding, University of Marburg, Germany Reviewed by Juan José Valdez Alarcón, Universidad Michoacana de San Nicolás de Hidalgo, Mexico Yuanqing Xu, Inner Mongolia Agricultural University, China Daniel Berean, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Romania Updates Copyright © 2024 Li, Sha, Li, Wang, Yang, Jiao and Zhao

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Chondrocytes from KOA tissues exhibit hallmark features of cuproptosis, including mitochondrial swelling and loss of cristae structure