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Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies - PMC

These metabolites can act as electrophiles and contribute to the production of ROS through redox cycling mechanisms (42, 74, 75), highlighting the dual nature of QUE’s biological effects

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Hepatic ADH, along with CYP2E1 and CAT (including in other tissues such as the brain [92]), are major enzymes that catalyze ethanol oxidation to a highly reactive and toxic metabolite, acetaldehyde, whereas ethanol-evoked oxidative stress is implicated in heart injury [93]