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Besides substrate availability, GCL is the rate-limiting enzyme in GSH synthesis, which presents two different subunits: the catalytic subunit (GCLC), containing the active site responsible for the bond formation between the amino group of cysteine and the γ-carboxyl group of glutamic acid, and the modifier subunit (GCLM) that interacts with GCLC, increasing the catalytic efficiency of GCLC [5]

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Study selection followed a structured framework aligned with the review's focus on oxidative stress in AD