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10.1016/j.jhep.2012.06.034 [DOI] [PubMed] [Google Scholar] 65.Dhingra R, Gona P, Wang TJ, et al
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Aconitum is widely recognized for its lethal neurotoxicity, with research primarily focused on aconitine and limited reports on MA-induced central nervous system toxicity ( A measure of 60 μM of aconitine was found to impede neuromuscular conduction in isolated diaphragm muscle by inhibiting the release of neurotransmitters, nerve action potentials, end-plate potentials, and indirect muscle action potentials ( 2+ signaling ( 2+ influx via the Na + /Ca 2+ exchangers in HUVECs and induced aorta dilatation ( Oxidative stress, characterized by an imbalance between ROS production and the cellular antioxidant defense system, often serves as a catalyst for mitochondrial structure and function damage ( MeRIP-seq, which combines RNA–protein immunoprecipitation with high-throughput sequencing technology, facilitates the analysis of m6A modification levels in RNA