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1–4 A so-called “therapeutic misadventure” phenomenon, as coined by Zimmerman et al ., is becoming increasingly acknowledged, as some patients have presented with acute liver failure despite consumption of “safe” doses of APAP

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Although AMPA/kainate receptor levels remain relatively constant or increase with age, the impaired ability for neurons to form new synaptic contacts with OPCs, combined with a decline in NMDA receptors, may decrease OPC differentiation and activity-dependent myelination in the aged brain (Spitzer et al., 2019