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Moreover, in retinal ECs, hyperglycemia and ROS production can induce the sustained overexpression of DNA (cytosine-5)-methyltransferase 1 (DNMT1), even after normalization of glucose levels (Mishra & Kowluru, 2016), maintaining a pathological epigenetic memory

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(40) demonstrated that topical application of Nile Crocodile oil lotion significantly improved skin hydration and elasticity while reducing scaling