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[DOI] [PubMed] [Google Scholar] 64.Neklason D.W., Done M.W., Sargent N.R., Schwartz A.G., Anton-Culver H., Griffin C.A., Ahnen D.J., Schildkraut J.M., Tomlinson G.E., Strong L.C., et al

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Direct delivery of respiratory drugs to the lungs bypasses systemic circulation, allowing higher local drug concentrations and reduced overall dosage need, thereby minimizing systemic side effects 98,99,108,109,111