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The Core Biology B12 acts as a cofactor for two critical enzymatic reactions: converting homocysteine to methionine (essential for DNA methylation) and converting methylmalonyl-CoA to succinyl-CoA (essential for energy metabolism)

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To achieve this special stoichiometry for c-MET activation, the activating HGF (i.e., HGF I) with an elongated shape simultaneously recruits two c-METs to its opposite ends