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In addition, transient receptor potential mucolipin 1 (TRPML1), a non-selective cation channel localized on lysosomal membranes, participates in maintaining iron balance through regulation of lysosomal exocytosis (177)

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Further, the 5,10-methylene-THF can then be converted by methylenetetrahydrofolate reductase into 5-methyl-THF, which is used for the remethylation of homocysteine to methionine