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There are two main ways to avoid excessive interaction of the gut microbiota with TLRs to prevent activation of the intestinal and in some cases systemic immune response: i) decreasing the expression of TLRs, and ii) moving TLRs from the plasma membrane into lysosomes (Semin et al., 2021)

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This was evidenced by decreased levels of IL-1, TNF-α, and IL-6, and increased levels of IFN-γ which led to an activated macrophagic response that restricted Mtb replication [70]