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In a more complex way, even before epithelial lesions, there were antecedent endothelial injury, thrombi, and stasis and thus Virchow triad circumstances (although not specifically claimed) that needed to be resolved [44,45,46,47]

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That rodent work is nonetheless specific, and it points at the mesolimbic reward system rather than the brainstem satiety circuits: Amylin receptors are co-expressed on dopamine neurons of the ventral tegmental area