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When, therefore, a purgative is brought up again, in which calomel was a component part, it may be suspected to arise from this source, and, if it is necessary to repeat the purge, the mercurial should be omitted.— Blaine

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Phase 1 corresponds to a high level of activity in the primary afferent as a result of C-fiber activation due to peripheral stimulation, whereas phase 2 results from a continuous low-level small afferent input, together with a facilitated state of spinal processing [21]