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The controllable Cas9 variant was further fused with deaminase APOBEC1, giving the resulting BaseBAC with the enzymatic activity of a cytosine base editor (CBE), which permits on-demand base editing on the GSDME gene, leading to the production of a truncated version of its N-terminal domain, which triggers pyroptosis

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The first three singles from Thriller —the poppy “The Girl Is Mine,” the funkier “Billie Jean,” and even the rock-edged “Beat It”—all topped the soul chart (Billboard called it “Black Singles” back then), which meant Epic’s worries about Michael’s Black fan base never materialized

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