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Its endocrine-disrupting potential stems from high-affinity binding to estrogen receptors, fundamentally altering hormonal balance ( 2.1.2.2 Flame retardants Polybrominated diphenyl ethers (PBDEs) exhibit remarkable biological persistence, with half-lives extending 3–7 years and high octanol-water partition coefficients (log Kow = 6.5-8.4), facilitating extensive bioaccumulation

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Diastereoisomer (2 S ,3 S )- 31 was also prepared employing the same methodology