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Presently, two phase-II clinical studies are ongoing that are using DCV primed with tumor samples, stem cells, and cytotoxic lymphocytes as a first-line treatment in GBM patients (NCT01759810), and the other trial is investigating the efficacy of mRNA-transfected DCV comparing adjuvant temozolomide (TMZ) in GBM patients (NCT03548571)

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10.1016/j.omtm.2021.11.003 189