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Although exact mechanisms are still unclear, CBD may inhibit endocannabinoid signaling and its effects on synaptic plasticity through negative allosteric modulation [83], while the enhancement of vasopressin and oxytocin release by CBD and other epigenetic modulations have also been proposed [78,84]

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In contrast, static ALI conditions showed a late decrease in TER and less pronounced cytotoxicity, emphasizing the importance of mechanical forces in exacerbating the effects of CS on the epithelial barrier (Fig