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Other symptoms manifested in sickle cell anemia carriers include severe bacterial infections, necrosis (tissue death), acute chest syndrome, ischemic and hemorrhagic stroke, sepsis, hemolytic crises, and functional asplenia [1]

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The administration of HGH to healthy older adult men with IGF-I concentration less than 0.35 U/mL showed a mean plasma IGF-1 level rose into the youthful range of 0.5–1.5 U/mL and this effect was dose-dependent (Marcus et al., 1990