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46 , 47 Whole-genome sequencing of 48 ovarian cancer (OVCA) revealed a novel p53 mutation, the TP53I3 p.S252X variant (rs145078765, MAF = 0.0016), which may decrease ROS production and dampen mitophagy in apoptosis, thus affecting the efficacy of several cytotoxic agents that target mROS production to induce apoptosis of tumor cells (33)