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An additional critical layer of pathophysiology involves alcohol-induced gut barrier dysfunction and microbiota dysbiosis, which promotes endotoxin translocation to the liver, thereby exacerbating immune-mediated inflammation and driving progression from steatosis to hepatitis and fibrosis (Wang et al., 2010)

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Such differences may be due to different AD subtypes, disease stages, and experimental methods, and also reflect the complexity of the histone acetylation process in AD

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