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A total of 607 patients received Pemetrexed for Injection, pembrolizumab, and platinum every 3 weeks for 4 cycles followed by Pemetrexed for Injection and pembrolizumab (n=405), or placebo, Pemetrexed for Injection, and platinum every 3 weeks for 4 cycles followed by placebo and Pemetrexed for Injection (n=202)

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As such, SERT is an important pharmacological target due to its role in extending 5-HT’s action within the synaptic cleft