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IV glutathione has no FDA-approved indication, no approved label, no controlled efficacy data for skin-whitening use, and documented safety concerns including renal toxicity, Stevens-Johnson syndrome, and neurological effects prompting the 2011 Philippines FDA advisory

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This inflammatory state induces goblet cell hyperplasia and submucosal gland hypertrophy within the airway epithelium, resulting in the overproduction of mucus that is abnormally thick and viscous [26]