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Pen Dosage Chart​ Dosage & Protocols Variations​ Standard Research Protocol Dose: 0.2 – 0.4 mg (variant 5 mg pen = 8-16 clicks / variant 10 mg pen = 4-8 clicks) Duration: 2 – 4 weeks Frequency: Daily Cycle Interval: 2 – 4 weeks off before repeating Goal / Description: Common dose for general recovery models

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Macrophage-derived IGF-1 promotes intestinal vascular endothelial cell proliferation in vivo in neonatal mice and protects against experimental NEC To examine the role of macrophage-derived IGF-1 on intestinal vascular endothelial cell proliferation in vivo, transgenic mice that express Cre recombinase driven by the Cx3cr1 promoter were bred with mice bearing loxP sites flanking exon 4 of the Igf 1 gene, to generate mice with IGF-1-deficient macrophages (Fig