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[DOI] [PMC free article] [PubMed] [Google Scholar] [166].Liu Y, Lu F, Kang L, Wang Z, Wang Y, Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium

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More broadly, the growing field of nano- and micro-delivery systems for natural bioactives shows that solid lipid nanoparticles, polymeric micelles, nanoemulsions, and self-emulsifying drug delivery systems (SEDDS) can dramatically improve solubility, protect labile compounds from degradation, and promote controlled release and tissue-targeted delivery (Teixé-Roig et al., 2023