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Delivery barriers in adipose-rich and desmoplastic TMEs (PDAC as an example) Dense ECM, elevated interstitial pressure, and poor perfusion constrain drug penetration in PDAC, where hyaluronan-rich stroma is a major determinant of vascular collapse and delivery failure

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If you're new to this whole category of ingredients, you can get up to speed on how they work in our detailed guide on peptide serums