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Sources of reactive oxygen, electrophile, and chlorine species (ROS, RES, RCS) Bacteria encounter ROS during respiration or by the oxidative burst of activated neutrophils during infections (Imlay, 2 ) leads to generation of superoxide anions (O 2 • − ), hydrogen peroxide (H 2 O 2 ) and the highly reactive hydroxyl radical (OH•) (Figure 1)