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Fatigue is one of the most common and debilitating symptoms experienced by patients diagnosed with MS, often significantly limiting daily activities, productivity, and overall quality of life

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Recent studies suggest that treatment with semaglutide (GLP-1RA) in combination with firsocostat (ACC-a inhibitor) and/or cilofexor (nonsteroidal FXR agonist) can further improve hepatic steatosis and thus NAFLD compared with semaglutide alone in exploratory efficacy analyses [113]