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Although classical AD comprises 85% of cases, there are other phenotypes, including the lipogenic variant of primary progressive aphasia, posterior cortical atrophy, corticobasal syndrome, and frontal AD [131]

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Further investigations targeting this disparity are warranted based on a study protocol designed to assess neurodegeneration and neuronal loss specifically in 5xFAD mice approaching one year of age (Zhang et al., 2021)