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The lead researcher has estimated roughly 10:1 selectivity, about one healthy cell affected for every ten senescent cells removed, which is one reason next-generation, more selective compounds are being developed instead

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New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice

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