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In addition to the two most common modifications above, the alpha-keto amide (alpha-keto-carbonyl amide) structure can be loaded on the C-terminal to introduce the keto-carbonyl group into the peptide molecule and transform it into a covalent peptide-like drug that can form a covalent bond with the receptor

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Those on immunosuppressants or with autoimmune conditions may want to discuss GHK-Cu use with healthcare providers given the peptide’s immune-modulating effects