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As Talpos's investigation recounts, the idea traces to 1975, when as a second-year medical student he reasoned that the stomach must produce a natural anti-stress healing substance, which he named Substancija Bože Pomozi, or "Substance God Help Me." His team gathered stomach fluid from clinics and pig slaughterhouses, screened it across years, and in 1989 reported a protein from which they identified the peptide they named BPC-157

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However, it is important to use pan-AKR inhibitors because inhibition of a single AKR may result in substitution by another AKR