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The central regulator of these inflammatory factors is nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is activated as a result of DNA damage 35

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Given the central role of NMDA receptors in tinnitus-related excitotoxicity and synaptic plasticity, NMDA receptor antagonists have been investigated as a rationally based therapeutic strategy, repurposing knowledge from neurodegenerative conditions like AD where drugs such as memantine are used (Rafe et al., 2024)