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GHSR1a dimerization with the melanocortin-3 receptor amplifies MC3R and inhibits GHSR1a signaling Within the arcuate nucleus, most GHSR1a-expressing neurons coexpress MC3R, while a much smaller proportion of MC3R-expressing neurons coexpress GHSR1a (Rediger et al., 2009)

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To maintain the benefits, follow-up treatments every 6-12 months are recommended